EPA Master List of PFAS Chemical

Per- and polyfluorinated alkyl substances (PFAS) represent a growing, increasingly diverse inventory of chemicals of interest to the general public, scientific researchers, and regulatory agencies world-wide. Accompanying data-gathering, testing, and environmental monitoring exercises, in turn, have led to the publication and sharing of various lists of PFAS chemicals, some exceeding several thousand substances. A major effort was undertaken by EPA researchers within the National Center for Computational Toxicology to curate and structure-annotate several public lists in DSSTox. The below list of registered PFAS lists, from within and outside EPA, encompass PFAS of potential interest based on environmental occurrence (through literature reports and analytical detection) and manufacturing process data, as well as lists of PFAS chemicals procured for testing within EPA research programs. The consolidated list contains a number of PFAS CAS-name substances, with a subset represented with defined chemical structures. There is no precisely clear definition of what constitutes a PFAS substance given the inclusion of partially fluorinated substances, polymers, and ill-defined reaction products on these various lists. Hence, PFASMASTER serves as a consolidated list of substances spanning and bounded by the below lists, defining a practical boundary of PFAS chemical space (within DSSTox) of current interest to researchers and regulators worldwide. This PFAS Master List will continue to expand as component lists grow. (Last Updated: August 10th 2021)